SrasV1, Main, Exploration, bibRecord, 003125

Development of subunit vaccines against severe acute respiratory syndrome.

Identifieur interne : 003125 ( Main/Exploration ); précédent : 003124; suivant : 003126

Development of subunit vaccines against severe acute respiratory syndrome.

Auteurs : Lanying Du [République populaire de Chine] ; Yuxian He ; Shibo Jiang ; Bo-Jian Zheng

Source :

Drugs of today (Barcelona, Spain : 1998) [ 1699-3993 ] ; 2008.

RBID : pubmed:18301805

Descripteurs français

KwdFr :
- Animaux, Conception de médicament, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (immunologie), Humains, Protéines de l'enveloppe virale (immunologie), Syndrome respiratoire aigu sévère (), Vaccins antiviraux, Vaccins sous-unitaires, Virus du SRAS (immunologie).
MESH :
- immunologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus du SRAS.
- Animaux, Conception de médicament, Glycoprotéine de spicule des coronavirus, Humains, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins sous-unitaires.

English descriptors

KwdEn :
- Animals, Drug Design, Humans, Membrane Glycoproteins (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (prevention & control), Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Envelope Proteins (immunology), Viral Vaccines.
MESH :
- chemical , immunology : Membrane Glycoproteins, Viral Envelope Proteins.
- immunology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Drug Design, Humans, Spike Glycoprotein, Coronavirus, Vaccines, Subunit, Viral Vaccines.

Abstract

Severe acute respiratory syndrome (SARS) is a novel infectious disease caused by SARS coronavirus (SARS-CoV). Although SARS appears to have been successfully contained, there is still a risk for its reemergence due to sporadic laboratory accidents or the presence of a natural reservoir for SARS-CoV-like virus. Therefore, the development of effective vaccines against SARS-CoV continues to be the current focus of SARS research. This review will first describe the rationale for developing safe and effective SARS vaccines, followed by elucidating viral antigens that could be used as potential vaccine components. After comparing current vaccine categories against SARS, this article will demonstrate the advantages of subunit vaccines, describe the current situation of developing subunit vaccines, and point out the possibility for further improvement of subunit SARS vaccines. This suggests that recombinant protein/peptide-based subunit vaccines containing the spike protein, especially the receptor-bind domain of SARS-CoV, could be developed as safe and effective SARS vaccines.

DOI: 10.1358/dot.2008.44.1.1131830
PubMed: 18301805

Affiliations:

République populaire de Chine

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of subunit vaccines against severe acute respiratory syndrome.</title>
<author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea>
<wicri:noRegion>Hong Kong SAR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name>
</author>
<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="RBID">pubmed:18301805</idno>
<idno type="pmid">18301805</idno>
<idno type="doi">10.1358/dot.2008.44.1.1131830</idno>
<idno type="wicri:Area/PubMed/Corpus">001C06</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C06</idno>
<idno type="wicri:Area/PubMed/Curation">001C06</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C06</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001B48</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B48</idno>
<idno type="wicri:Area/Ncbi/Merge">001B85</idno>
<idno type="wicri:Area/Ncbi/Curation">001B85</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001B85</idno>
<idno type="wicri:doubleKey">1699-3993:2008:Du L:development:of:subunit</idno>
<idno type="wicri:Area/Main/Merge">003215</idno>
<idno type="wicri:Area/Main/Curation">003125</idno>
<idno type="wicri:Area/Main/Exploration">003125</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Development of subunit vaccines against severe acute respiratory syndrome.</title>
<author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea>
<wicri:noRegion>Hong Kong SAR</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name>
</author>
<author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
</author>
<author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</author>
</analytic>
<series><title level="j">Drugs of today (Barcelona, Spain : 1998)</title>
<idno type="ISSN">1699-3993</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Drug Design</term>
<term>Humans</term>
<term>Membrane Glycoproteins (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (prevention & control)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccines, Subunit</term>
<term>Viral Envelope Proteins (immunology)</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Conception de médicament</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires (immunologie)</term>
<term>Humains</term>
<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Syndrome respiratoire aigu sévère ()</term>
<term>Vaccins antiviraux</term>
<term>Vaccins sous-unitaires</term>
<term>Virus du SRAS (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term>
<term>Protéines de l'enveloppe virale</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Drug Design</term>
<term>Humans</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vaccines, Subunit</term>
<term>Viral Vaccines</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Conception de médicament</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Humains</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Vaccins antiviraux</term>
<term>Vaccins sous-unitaires</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a novel infectious disease caused by SARS coronavirus (SARS-CoV). Although SARS appears to have been successfully contained, there is still a risk for its reemergence due to sporadic laboratory accidents or the presence of a natural reservoir for SARS-CoV-like virus. Therefore, the development of effective vaccines against SARS-CoV continues to be the current focus of SARS research. This review will first describe the rationale for developing safe and effective SARS vaccines, followed by elucidating viral antigens that could be used as potential vaccine components. After comparing current vaccine categories against SARS, this article will demonstrate the advantages of subunit vaccines, describe the current situation of developing subunit vaccines, and point out the possibility for further improvement of subunit SARS vaccines. This suggests that recombinant protein/peptide-based subunit vaccines containing the spike protein, especially the receptor-bind domain of SARS-CoV, could be developed as safe and effective SARS vaccines.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name>
<name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
<name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003125 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003125 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:18301805
   |texte=   Development of subunit vaccines against severe acute respiratory syndrome.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:18301805" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

Serveur d'exploration SRAS

Development of subunit vaccines against severe acute respiratory syndrome.

Development of subunit vaccines against severe acute respiratory syndrome.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.